- Tamsulosin is a specific blocker of postsynaptic alpha-adrenoceptors located in the smooth muscle of the prostate, bladder neck and prostatic urethra. Alpha-adrenergic blockade tamsulosin leads to a reduction in smooth muscle tone of the prostate, bladder neck and prostatic urethra and improve urine flow. At the same time decrease as the symptoms of emptying and filling symptoms caused by increased tone of smooth muscle and detrusor overactivity in benign prostatic hyperplasia.
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The ability to influence the alpha Tamsulosin A adrenoceptor subtype 20 times its ability to interact with alpha adrenoceptor subtype B, which are located in vascular smooth muscle. Due to its high selectivity, tamsulosin does not cause a clinically significant reduction in systemic blood pressure in patients with hypertension, and in patients with normal baseline BP.
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